鈦金屬植體微電弧電漿氧化表面處理技術與骨組織的關係－小型文獻回顧

The Relationship between the Bone Response and Surface Modification of Ti Implants by micro-arc oxidation-a mini-review

白馨(Hsin Pai) ； 呂炫堃(Hsein-Kun Lu)

《中華牙醫學雜誌（中文版）》 26卷2期 (2007/12) Pp. 106-113

https://doi.org/10.7106/CJD.200712.0106

摘要

動機與目的：近年來經金屬溼式微電弧電漿氧化表面處理技術(micro-arc osidation CMAO) technology) 在鋁、鎂、及鈦合金等輕金屬表面氧化處理的應用逐漸受到重視，這是一種簡便快速之輕金屬表面處理方法。本篇文章討論在鈦試片上施以溼式微電弧電漿法表面處理，改變表面結構與化學組成，並進而探討共生物效應：如骨母細胞的貼附、展開、生長及分化，與動物實驗中移除扭力與組織學的檢驗，並藉由初步的生物測試結果來評估輕金屬工業表面處理技街應用在臨床人工植骨研究的發展潛力。材料與方法：由數篇論文中歸納其初步的細胞測試與動物實驗結果，以探討MAO表面處理技術的生物效應與分析未來可行的研究方向。結果：施與MAO於欲試片上，能夠提供表面俊的孔洞性與粗糙度，而微結構的改變可以進一步促進氫氧基磷灰石塗層的生成作用。初步的生物測試結果表示，MAO表面處理技術具有良好的生物效應，對於骨生成有正向的效果，但表面巨型態與微結構各別的差異對於細胞組織的影響機制仍有待未來進一步的研究。結論：由初步的實驗結果得到，MAO表面處理技術對於骨整合有潛在的正向效果，在植體研究領域裡具有很高的發展潛力。

關鍵字

微電弧電漿氧化表面處理技術 ； 鈦金屬 ； 骨組織

並列摘要

Background: In recent years, micro-arc oxidation (MAO) plasmo-electrolytic treatment (MAPET) of the surface of valve metals, such as aluminum, magnesium, and titanium alloys, has gained increasing attention since it is a simple and rapid surface modification technology. The aim of the study was to discuss the surfaces of titanium discs which were treated by MAO technology; changes in the surface structure and chemical composition; biological effects like the attachment, spread, proliferation, and differentiation of osteoblastic cells; removal torque test results in an animal study; and histological examinations. Through the preliminary in vitro tests, we hoped to estimate the potential for the application of MAO technology to implant research by examining its clinical performance. Materials and methods: We summarized the results of the preliminary in vitro and in vivo tests from several articles to discuss the biological effects of MAO surface modification technology, and estimated its further development. Results: Titanium discs surface-treated by MAO technology exhibited excellent porosity and roughness. Changes in the microstructure may further promote hydroxyl apatite generation. Results of the preliminary tests showed that surfaces modified by the MAO technology had excellent biocompatibility. They had positive effects on bone tissue regeneration, but the mechanisms through which the macro-topography and microstructure result in cell responses are still unclear. Conclusions: In the present study, MAO surface modification technology had positive effects on osseoregeneration, and may have high potential for improving implant research.

並列關鍵字

Micro-arc oxidation MAO technology ； titanium ； bone