Molar-incisor hypomineralization (MIH) is a developmental defect of the enamel of one or more permanent first molars with or without affecting incisors. The clinical symptoms and signs vary from case to case and between teeth in the same individual, including hypersensitivity, enamel breakdown, dental caries and pulpal inflammation. The affected enamel shows increased amount of proteins that leads to lower hardness and lower modulus of elasticity. The affected enamel can be a well-defined area or including the entire crown. After the hypomineralized molars erupted, there may be enamel fracturing and wearing. Early enamel loss can cause dental caries and rapid deterioration of the clinical crown. There are two cases in this case report. One is a 7-year-old boy with hypomineralized enamel of teeth 16 and 26. The other is a 6-year-old girl who has four hypomineralized permanent first molars with different severity. The discussion focuses on clinical symptoms and signs and how treatment strategies are made.