In the background of the great health, the higher and higher colleges pay more attention to the cultivation of the students' health literacy. The college students are in the transition stage from puberty to adulthood, and the university should play a leading role as the main place for college students to live. At present, the college students' life is becoming more and more abundant, and how to intervene in the college students' life is the primary task of the development of physical education in colleges and universities, and is an important way to train the health literacy of the college students. Therefore, this article will briefly outline the characteristics of the times of the great health background, and then probe into the way of the college physical education to the college students' health literacy.