微針微射出成型之概念設計

Conceptual design of microinjection molding for manufacturing microneedles

羅悦慈(Yueh-Tzu Lo)

指導教授 ： 陳銘凱

淡江大學/理學院/化學學系碩士班/碩士(2021年)

https://doi.org/10.6846/TKU.2021.00287

摘要

一般而言經皮輸送的藥物只能傳遞小分子量的藥物，大部分的水溶性藥物無法有效地傳遞，主要原因是因為皮膚上的角質層屬於疏水性且帶電荷，而微針作為一種新一代的經皮輸送系統，主要是想克服皮膚角質層的阻礙，順利將藥物輸送製體內。本研究是採用微射出成型的概念製作微針貼片，且以可溶性高分子和食品用增稠劑為材料，透過改變兩個高分子的組成，再經由注射幫浦製備出不同組成的微針貼片。
　　通過手持顯微鏡及掃描式電子顯微鏡可觀察微針貼片脫模後的表面型態，而透過穿刺實驗確認以微射出成型製作微針貼片的機械強度並未降低，另外透過使用trypan blue釋放測試評估其不同組成微針貼片的釋放情形。

關鍵字

可溶式微針貼片 ； 經皮輸送

並列摘要

In general,transderaml drug delivery system (TDDS) only delivers the low-molecular weight drug. But most of the water-soluble drug can’t be efficiently transmitted, because the stratum corneum of skin is hydrophobic and charged. Microneedle(MN) patchs are a new generation of TDDS products. The purpose of the MN is to overcome the barriers of the stratum corneum and to deliver drugs into the body smoothly.
This study uses the concept of injection molding for manufacturing of MN. The MN are composed of two meterials. The MN had different ratio of two polymers composition for gaining different viscosity. This study uses the injection pump to manufacture the different composition ratio of MN.
The surface morphology of the MN after demolding can be observed through the handheld microscope and the scanning electron microscope. The purpose of puncture experiment is to identify the mechanical strength of the MN which is used the concept of injection molding for manufacturing of MN methods. The trypan blue release experiment is used evaluate the release amounts of its different compositions ratio.

並列關鍵字

Dissolving microneedles patch ； Transdermal delivery

參考文獻

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