熱熔射噴塗製備鋅摻雜氫氧基磷灰石塗層之製程及性質分析

本研究係利用共沉法來製備合成鋅摻雜的氫氧基磷灰石，目的是希望讓人工骨骼材料具有抗菌能力。實驗中以添加不同濃度的氯化鋅來進行共沉法，以TGA檢測熱重損失，以熱裂解溫度分階段制定煅燒溫度。利用XRD檢測，實驗結果顯示經過煅燒後，發現添加氯化鋅濃度0.05 M以上時會出現些微氧化鋅與磷酸鋅鈣的新相。添加氯化鋅濃度到達0.15 M時，新相強度高過氫氧基磷灰石相成為主要存在的相。進行定性抗菌測試方法中的抑菌圈產生法測試，實驗中添加氯化鋅濃度由0.0125 M增加至0.15 M，結果顯示抗菌性隨鋅含量提高而上升。為模擬人工骨骼，以火焰噴塗法將過篩造粒後的粉末噴塗至Ti-6Al-4V基材上，進行平面及橫截面SEM觀察，發現鋅摻雜氫氧基磷灰石粉末以多孔結構方式存在，孔隙率明顯提升。進行抗菌測試，發現試片具有良好的抗菌性，抑菌率隨著試片與菌液的接觸時間增加而提升。進行細胞測試的生物活性及毒性測試，發現試片具有良好的生物相容性。

關鍵字

氫氧基磷灰石；共沉法；抗菌

並列摘要

In this study, we prepared zinc-doped hydroxyapatite by the co-precipitation method, the purpose is to make artificial bone material has ability of antibacterial. The co-precipitation method prepared hydroxyapatite with add different concentrations of zinc chloride. Detected the weight loss by TGA to determine the sintering temperature of the pyrolysis temperature.Detected by XRD, the experimental results show that after sintering, it has some new phases generated of ZnO and CaZn2 (PO4)2, and the strength of new phases will high over than hydroxyapatite phase to be the major presence when we add zinc chloride that concentration reaches 0.15M. Testing antibacterial ability by the inhibition zone method of qualitative antibacterial test methods, the results shows that ability of antibacterial increased when the concentration of zinc chloride increased from 0.0125M to 0.15M. For simulate the artificial bone, the granulated powder that after sieved prilling were coated on the surface of Ti-6Al-4V substrate by the flame-spraying method, the SEM of surface topography and cross-section found that the zinc-doped hydroxyapatite was the porous structure on the substrate, and the porosity improved significantly. The antibacterial test found the specimen has a good antibacterial ability, the inhibition rate will increase when the time contacting by the specimen and bacteria increased. For biological activity and toxicity test of the cell test, the specimen was found with good biocompatibility.

並列關鍵字

hydroxyapatite ； co-precipitation method ； antibacterial

參考文獻

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[10] 鍾仁傑，以溶膠-凝膠法製備含鋅及銀之氫氧基磷灰石與其抗菌性質研究，碩士論文，清華大學材料科學工程研究所，新竹，2000。

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[22] Mohammad R. Saeri, Abdollahe Afshar, Mohammad Ghorbani, Naser Ehsani and Charles Chris Sorrell, "The wet precipitation process of hydroxyapatite," Materials Letters, 2003, 57, 4064-4069.

[24] J. Zhou, X. Zhang, J. Chen, S. Zeng, Klaas de Groot, "High temperature characteristics of synthetic hydroxyapatite," Journal of Materials Science-Materials in Medicine, 1993, 4(1), 83-85.

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熱熔射噴塗製備鋅摻雜氫氧基磷灰石塗層之製程及性質分析

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