標靶藥物和免疫治療在葡萄膜炎疾病治療之角色

The Role of Target Therapy and Immunotherapy in the Treatment of Uveitis

陳彥慈(Yen-Tzu Chen) ； 葉伯廷(Po-Ting Yeh)

《台灣醫學》 25卷4期 (2021/07) Pp. 512-515

https://doi.org/10.6320/FJM.202107_25(4).0010

摘要

非感染性葡萄膜炎的治療，主要使用皮質類固醇以及各類免疫抑制藥物，近年來快速研發的單株抗體類免疫調節藥物是未來相當有潛力的治療新選擇，這篇文章簡介數種單株抗體類免疫調節藥物及其相關臨床試驗的結果。

關鍵字

非感染性葡萄膜炎 ； 單株抗體 ； 免疫調節

並列摘要

The management of non-infectious uveitis includes topical and systemic corticosteroid therapy and a variety of immunomodulatory agents. Immunomodulatory monoclonal antibodies are actively researched and may be applied to the treatment of non-infectious uveitis. This essay briefly introduced a few types of immunomodulatory monoclonal antibodies and the results of related clinical studies.

並列關鍵字

non-infectious uveitis ； monoclonal antibody ； immunomodulation

參考文獻

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Jaffe GJ, Dick AD, Brezin AP, et al. Adalimumab in patients with active noninfectious uveitis. N Engl J Med 2016;375: 932-43.

Nguyen QD, Merrill PT, Jaffe GJ, et al. Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial. Lancet 2016; 388:1183-92.

Ramanan AV, Dick AD, Benton D, et al. A randomised controlled trial of the clinical effectiveness, safety and cost-effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis (SYCAMORE Trial). Trials 2014;15:14.