石蓮萃取物對代謝症候群受試者血糖、血脂、血壓、氧化壓力及發炎之影響

Effects of Graptopetalum paraguayense E.Walther extracts on blood glucose, blood lipids, blood pressure, oxidative stress, and inflammation in the subjects with metabolic syndrome

劉人慈(Jen-Tzu Liu)

指導教授 ： 楊乃成

中山醫學大學/健康管理學院/營養學研究所/碩士(2013年)

https://doi.org/10.6834/CSMU.2013.00073

摘要

研究發現代謝症候群（metabolic syndrome, MS）患者有較高之氧化壓力與發炎反應。石蓮（Graptopetalum paraguayense E. Walther）為薔薇目景天科的多年生肉質草本植物，近年為中南部農會推廣栽種之保健植物。本研究目的探討MS受試者使用石蓮水萃取物（Graptopetalum paraguayense E. Walther water extracts, GWE）（4公克/天），對脂質過氧化指標、抗氧化酵素活性、抗氧化維生素濃度及發炎指標之影響。MS患者從中山醫學大學附設醫院家醫科招募（n = 54），隨機給予安慰劑（n = 28）及GWE（n = 26）。測量受試者空腹血糖、血壓（收縮壓及舒張壓）、血脂（總膽固醇、三酸甘油酯、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇）、脂質過氧化指標（丙二醛）、抗氧化酵素活性（超氧化物歧化酶、麩胱甘肽過氧化酶及過氧化氫酶）、抗氧化維生素（維生素A和E）濃度及發炎指標（高敏感C-反應蛋白、介白素-6、腫瘤壞死因子-α和脂締素）。有42位受試者完成12週介入試驗（安慰劑組，n = 19；GWE組，n = 23）。結果發現，介入12週後，GWE組之高密度脂蛋白膽固醇濃度（p = 0.01）及抗氧化酵素（超氧化物歧化酶及過氧化氫酶，p < 0.01）活性顯著高於安慰劑組；空腹血糖（p = 0.04）、收縮壓（p = 0.01）、低密度脂蛋白膽固醇濃度（p = 0.04）及發炎指標（高敏感C-反應蛋白、介白素-6及腫瘤壞死因子-α，p < 0.05）濃度顯著低於安慰劑組。組內比較發現，GWE組介入12週後，可顯著提升高密度脂蛋白膽固醇濃度（p = 0.02）及抗氧化酵素活性（超氧化物歧化酶及過氧化氫酶，p < 0.05）；降低收縮壓（p < 0.01）、發炎指標（高敏感-C反應蛋白及腫瘤壞死因子-α，p < 0.05）濃度。由以上結果推論，MS患者使用GWE可輔助調節血脂與血壓，並提升其抗氧化酵素活性與降低發炎反應。

關鍵字

石蓮 ； 代謝症候群 ； 抗氧化 ； 發炎 ； 血壓 ； 血脂

並列摘要

A high oxidative stress and inflammation may contribute to the pathogenesis of metabolic syndrome (MS). Graptopetalum paraguayense E. Walther is a traditional Chinese herbal medicine and is widely consumed in Taiwan. The purpose of this study was to investigate the effect of aqueous extract of (Graptopetalum paraguayense E. Walther water extracts, GWE) (4 g/day) on the levels of lipid peroxidation, antioxidant enzymes activities, antioxidant vitamins, and inflammatory markers in patients with MS. Subjects with MS were recruited from the Department of Family and Community Medicine of Chung Shan Medical University Hospital in Taiwan (n = 54) and randomly assigned to the placebo (n = 28) and GWE (n = 26) groups. The levels of fasting glucose (FG), blood pressure [systolic blood pressure (SBP) and diastolic blood pressure (DBP)], lipid profiles [total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C)], malondialdehyde (MDA), antioxidant enzymes activities [superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT)], antioxidant vitamins (vitamin A and E), and inflammatory markers [high sensitivity-C reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and adiponectin (AD)] were measured. Forty-two subjects were completed 12 weeks intervention (placebo groups, n = 19; GWE groups, n = 23). Subjects in the GWE group had significantly higher levels of HDL-C (p = 0.01), antioxidant enzymes activities (SOD and CAT, p < 0.01), and lower FG (p = 0.04), SBP (p = 0.01), LDL-C (p = 0.04), inflammatory markers (hs-CRP, IL-6 and TNF-α, p < 0.05) than the placebo group at week 12. The levels of HDL-C (p = 0.02), antioxidant enzymes activities (SOD and CAT, p < 0.05) were significantly increased and the levels of SBP (p < 0.01), inflammatory markers (hs-CRP and TNF-α, p < 0.05) were significantly decreased in GWE group after 12 weeks administration. In conclusion, administration of GWE 4 g per day to MS subjects may assist in modulating the levels of blood pressure and blood lipid, increase antioxidant enzymes activities, and reduce the inflammation.

並列關鍵字

Graptopetalum paraguayense E ； Walther ； metabolic syndrome ； antioxidation ； inflammation ； blood pressure ； blood lipid.

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