Effects of Norepinephrine on Isolated Rabbit Aorta at Different Temperatures

體溫的變化是影響生物體生理功能的因素之一，早期有學者提出溫度對於兔子體表動脈血管（cutaneous arteries）具影響，並發現低溫會引起內皮（endothelium）產生一氧化氮（nitric oxide, NO）舒張血管，以防止血管因低溫過度攣縮（cold-induced cutaneous vasospasm），對於深層血管（deep vessels）例如主動脈血管（aorta）的溫度連續變化的影響研究報告尚少。本實驗結果顯現，當存在血管的溫度低於37°C時，其收縮力較弱：隨著溫度增加，收縮力增加；反之，隨溫度降低，血管收縮力亦降低，呈現溫度依存性（temperature-dependence）。並且觀察到norepinephrine在不同溫度時收縮力亦不同，37°C時血管收縮力最大，而20°C時收縮力最小。由以上實驗顯示，在家兔的離體主動脈血管實驗中，器官槽中的溫度選擇以35°至37°C反應能力最佳。

關鍵字

不同溫度；血管平滑肌

並列摘要

The change in body temperature is one of the most important factors in physiological functions. Early studies have suggested that the cutaneous arteries of the rabbit are influenced by temperature changes. Low temperature stimulates the release of nitric oxide from the endothelium and prevents a cold-induced vasospasm by relaxation of the vessels. However, the influence of temperature changes on deep vessels is not clear. The preparation of isolated rat aortic strips was used in this study. The temperatures in the organ bath were changed, using a thermometer as a guide. From our results, the isolated rabbit aorta relaxed when the organ bath temperature was lowered from 37℃ to 20℃. The tension of the vascular smooth muscle increased when the temperature was increased from 20℃ to 37℃. Norepinephrine-induced contraction in the isolated rabbit aorta was influenced by different temperatures. The optimal temperature for the isolated rabbit aorta was 35℃ to 37℃ in the in vitro experiment.

並列關鍵字

different temperatures ； norepinephrine ； vascular smooth muscle

國際替代計量

Effects of Norepinephrine on Isolated Rabbit Aorta at Different Temperatures

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