Diagnostic Values of Carcinoembryonic Antigen, Cancer Antigen 15-3 and Cancer Antigen 125 Levels in Nipple Discharge

Song Zhao ； Xiaodong Gai ； Yongmei Wang ； Weili Liang ； Haidong Gao ； Kai Zhang ； Huimin Wang ； Yanhong Liu ； Jianli Wang ； Rong Ma

《The Chinese Journal of Physiology》 58卷6期 (2015/12) Pp. 385-392

https://doi.org/10.4077/CJP.2015.BAD336

並列摘要

An expedient and cost-effective diagnostic tool is needed to complement galactography and exfoliative cytology for detection of benign or malignant breast diseases with nipple discharge. The aim of this prospective study is to explore the utility of carcinoembryonic antigen, cancer antigen 15-3 and cancer antigen 125 levels in nipple discharge for the diagnosis of various breast diseases. We evaluated the pre-operative tumor marker levels in 153 nipple discharge samples collected from one or both breasts of 142 women undergoing surgery. Patients with nipple discharge underwent auxiliary examination (ultrasonography, exfoliative cytology, ductoscopy and galactography). Statistically higher levels of carcinoembryonic antigen and cancer antigen 15-3 were found in patients in the malignant group as compared to those in the benign group. No statistically significant difference in the level of cancer antigen125 (P = 0.895). Sensitivities of carcinoembryonic antigen and cancer antigen 15-3 for diagnosing breast cancer were 74.42% and 58.14%, and specificities were 87.27% and 80.00% where as the cutoff values with max-sum of sensitivity and specificity were 224.3 ng/ml and 1368.2 U/ml, respectively. The following sensitivities for telling malignant from benign could be determined: exfoliative cytology 46.67%, ultrasonography 76.74%, galactography 75.00%, and ductoscopy 0%. Exfoliative cytology was found to be a valuable alternative method for differentiating benign from malignancy. Thus, tumor marker analysis of nipple discharge fluid for carcinoembryonic antigen and cancer antigen 15-3 would enhance the accurate assessment and treatment planning for patients with nipple discharge.

並列關鍵字

breast cancer ； cancer antigen 15-3 ； carcinoembryonic antigen ； diagnosis ； imaging examination ； nipple discharge ； tumor marker

參考文獻

Barak, V.,Goike, H.,Panaretakis, K.W.,Einarsson, R.(2004).Clinical utility of cytokeratins as tumor markers.Clin. Biochem.37,529-540.

Bast, R.C., Jr.,Klug, T. L.,St John, E.,Jenison, E.,Niloff, J. M.,Lazarus, H.,Berkowitz, R. S.,Leavitt, T.,Griffiths, C. T.,Parker, L.,Zurawski, V. R., Jr.,Knapp, R.C.(1983).A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer.N. Engl. J. Med..309,883-887.

Blixt, O.,Bueti, D.,Burford, B.,Allen, D.,Julien, S.,Hollingsworth, M.,Gammerman, A.,Fentiman, I.,Taylor-Papadimitriou, J.,Burchell, J. M.(2011).Autoantibodies to aberrantly glycosylated MUC1 in early stage breast cancer are associated with a better prognosis.Breast Cancer Res..13,R25.

Cyr, A. E.,Margenthaler, J. A.,Conway, J.,Rastelli, A. L.,Davila, R. M.,Gao, F.,Dietz, J. R.(2011).Correlation of ductal lavage cytology with ductoscopy-directed duct excision histology in women at high risk for developing breast cancer: a prospective, singleinstitution trial.Ann. Surg. Oncol..18,3192-3197.

Dinkel, H. P.,Trusen, A.,Gassel, A. M.,Rominger, M.,Lourens, S.,Muller, T.,Tschammler, A.(2000).Predictive value of galactographic patterns for benign and malignant neoplasms of the breast in patients with nipple discharge.Brit. J. Radiol..73,706-714.