Hemorrhagic Hepatocellular Adenoma Occurring in a Patient with Hyperaldosteronism

一位高醛固酮症患者發生出血性肝細胞腺瘤

林煒晟(Wei-Chen Lin) ； 王蒼恩(Tsang-En Wang) ； 王朝弘(Chao-Hung Wang) ； 楊博勝(Po-Sheng Yang) ； 王鴻源(Horng-Yuan Wang)

《台灣癌症醫學雜誌》 30卷1期 (2014/03) Pp. 65-69

https://doi.org/10.6323/JoCRP.2014.30.1.9

摘要

肝細胞腺瘤是一種罕見、良性且來源不明的腫瘤。它主要發生在長期服用避孕藥的年輕成年女性。Spironolactone是廣泛使用的利尿劑。儘管spironolactone經常使用，極少有肝細胞毒性的報導。至目前為止，沒有英文文獻在關於高醛固酮症患者伴有肝細胞腺瘤使用spironolactone的報告。在此，我們提出了一個長期spironolactone治療下的高醛固酮症患者伴有肝細胞腺瘤。 肝細胞腺瘤發生擴大和出血性變化。所以在治療這類患者，eplerenone或手術介入可能優於spironolactone。

關鍵字

肝細胞腺瘤 ； 高醛固酮 ； 腎上腺皮質腺瘤

並列摘要

Hepatocellular adenoma (HCA) is a rare, benign neoplasm of uncertain origin. It occurs predominantly in young adult women using long-term oral contraceptives. Spironolactone is a widely used diuretic agent. Despite the frequent use of spironolactone, there have been very few cases of hepatocellular toxicity reported. Furthermore, there are no reports to date in the English literature about HCA associated with spironolactone treatment for hyperaldosteronism. Herein, we present a HCA patient with hyperaldosteronism, who received spironolactone treatment for an extended period of time. The patient's HCA was enlarged and underwent hemorrhagic change. Therefore, eplerenone or surgical intervention may be superior to spironolactone in this patient.

並列關鍵字

hepatocellular adenoma ； hyperaldosteronism ； adrenal cortical adenoma ； spironolactone