合併苦瓜和芭樂葉萃取物對第2型糖尿病大鼠血糖的影響

Antidiabetic Effects of Momordica Charantia and Psidum Guajava Extract in Type II Diabetes Rats

江盈穎(Ying-Ying Chaing) ； 徐近平(Chin-Ping Hsu) ； 簡廷易(Ting-Yi Chien) ； 蔡均函(Chun-Han Tsai) ； 高鈺祐(Yu-Yo Kao) ； 趙煥鈞(Huan-Chun Chao) ； 黃惠宇(Hui-Yu Huang)

《臺灣營養學會雜誌》 37卷2期 (2012/06) Pp. 66-74

https://doi.org/10.6691/NSJ.201206_37(2).0002

摘要

先前研究指出，攝取天然多酚類成分可以有效降低高血糖現象及降低代謝症候群因子的發生，因此本研究主要探討富含多酚類之苦瓜及芭樂葉萃取物，是否有助於降低高血糖的功效。本實驗利用高脂飲食並施打Streptozotocin（STZ）誘發糖尿病大鼠模式進行研究，並且分為控制組（SHF）以及灌食苦瓜及芭樂葉萃取物之試驗組A、B 及C（36.5、182.3及364.6 mg /kg /day）。實驗期間每週分別測糖尿病大鼠體重、血糖、胰島素值及糖化血色素等生化值，且於第8週犧牲前進行OGTT試驗分析。結果顯示，於糖尿病大鼠模式之下，苦瓜芭樂葉萃取物可抑制高脂飲食及STZ誘發的高血糖的現象（p ＜ 0.05），並改善血清中胰島素分泌及延緩糖尿病的嚴重度。

關鍵字

胰島素 ； 苦瓜多酚 ； 第二型糖尿病 ； 芭樂葉多酚 ； 血糖

並列摘要

Bitter melon and guava leaf are rich in polyphenols which exert beneficial health effects to ameliorate metabolic diseases. In the present study, we examined the effects of bitter melon and guava leaf extract (EBGL) on hyperglycemia in rats given a high-fat diet and with diabetes induced by low-dose streptozotocin. Diabetic rats were then randomly separated into a diabetic group and different EBGL dosage treatment groups (groups A, B, and C at 36.5, 182.3, and 364.6 mg/kg/day, respectively). The body weight, serum glucose level, insulin level, [glycated hemoglobin (HbA1c), and Oral Glucose Tolerance Test (OGTT) were measured at optimal time intervals of the experimental duration. Results showed that treatment of diabetic rats with EBGL dramatically reduced the fasting blood glucose and HbA1c, and also improved serum insulin secretion and OGTT relative to the untreated diabetic group ( p ＜ 0.05). Treatment groups showed lower weigh gain compared to the untreated diabetic group. However, chronic treatment of diabetic rats with EBGL could prevent abnormal changes in blood glucose and attenuate the development of diabetes.

並列關鍵字

insulin ； guava leaf ； bitter melon ； type II diabetes ； blood glucose