The objective of this study was to evaluate the immunomodulatory effects of the freeze-dried powder obtained from the water extract of Chinese medicinal plant Echinops grijsii. In vitro immunomodulatory experiments showed that E. grijsii (0-400 μg/mL) stimulated RAW 264.7 macrophages to produce NO and secrete TNF-α in a dose-dependent manner. Moreover, E. grijsii significantly (P<0.05) promoted the IFN-γ secretion of mouse splenocytes. The results showed that the water extract of E. grijsii had immunomodulatory functions as well as potentials in related medicinal applications.
The objective of this study was to evaluate the immunomodulatory effects of the freeze-dried powder obtained from the water extract of Chinese medicinal plant Echinops grijsii. In vitro immunomodulatory experiments showed that E. grijsii (0-400 μg/mL) stimulated RAW 264.7 macrophages to produce NO and secrete TNF-α in a dose-dependent manner. Moreover, E. grijsii significantly (P<0.05) promoted the IFN-γ secretion of mouse splenocytes. The results showed that the water extract of E. grijsii had immunomodulatory functions as well as potentials in related medicinal applications.