豬增生性壞死性肺炎在台灣的發生概況

回溯性研究分析民國91至92年間台灣地區33個養豬場，275個臨床上有呼吸困難、呼吸急促及腹式呼吸等症狀之離乳後至肥育前期豬隻，經組織病理學檢查有50例(18%)診斷為增生性壞死性肺炎，其特徵為肺泡有明顯單核細胞增生，肺間質變厚且肺泡腔有許多單核細胞及脫落壞死細胞之蓄積。以細菌分離及PCR分析其病因，發現細菌及病毒混合感染佔49例，僅有一例為單純第二型豬環狀病毒感染，進一步病毒性病原交叉分析，第二型豬環狀病毒佔100%，豬生殖與呼吸道綜合症病毒佔12%，細菌性病原有沙氏桿菌、黴漿菌、巴氏桿菌、鏈球菌及大腸桿菌各佔26%、22%、4%、4%及4%。另外，以原位雜交法或免疫化學染色法分析病灶中的病毒性病原，發現第二型豬環狀病毒佔88%(44/50)豬生殖與呼吸道綜合症病毒佔28%(14/50)，豬流行性感冒病毒佔38%(19/50)，豬小病毒佔84%(42/50)。由上述結果顯示，台灣地區豬增生性壞死性肺炎有一定之比例發生，且多因病毒與細菌混合感染所致。

關鍵字

台灣地區；增生性壞死性肺炎；混合感染；豬

並列摘要

Two hundred and seventy-five pneumonic cases collected between 1992 and 1993 from 33 pig farms in Taiwan were included in this study. The main clinical signs of these postweaning and nursing pigs included tachypnoea, dyspnea and abdominal respiration. Fifty cases (18%) of proliferative and necrotizing pneumonia (PNP) were diagnosed histopathologically and the lesions were featuring with thickening of alveolar septa by infiltration of macrophages/or mononuclear cells and accumulation of numerous desquamous cells, necrotic debris and inflammatory cells in the alveolar spaces. The etiology of PNP was the combined infection of bacterial and viral pathogens decided by polymerase chain reaction (PCR) and bacterial isolation. The detection rate in PNP lesion showed that porcine circovirus type 2 (PCV2) was 100 %, porcine reproductive and respiratory syndrome virus (PRRSV) was 12 %, Salmonella spp. was 26%, Mycoplasma spp. was 22%, Pasteurella spp. was 4% and E coil was 4%. In addition, using in situ hybridization (in situ) or immnunohistochemistry (IHC) to detect viral pathogens in the PNP lesions, the results revealed PCV2 was 88% (44/50), PRRSV was 28% (14/50), swine influenza virus (SIV) was 38% (19/50), and porcine parvovirus (PPV) was 84% (42/50). The results of the present study demonstrated that viral and bacterial agents were consistently and predominantly associated with PNP in Taiwan.

並列關鍵字

Taiwan ； proliferative and necrotizing pneumonia ； mixed infection ； piglet

被引用紀錄

蕭君倪（2010）。建立偵測常見豬隻呼吸道病毒性疾病即時聚合酶鍊鎖反應技術〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2010.02189

國際替代計量

豬增生性壞死性肺炎在台灣的發生概況

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