Decreased White Blood Cell Count Related to Haloperidol Add-on Treatment to Olanzapine

併用Haloperidol於Olanzapine後出現白血球降低

黃偉烈(Wei-Lieh Huang) ； 林朝誠(Chao-Cheng Lin) ； 廖士程(Shih-Cheng Liao)

《台灣精神醫學》 25卷2期 (2011/06) Pp. 115-118

https://doi.org/10.29478/TJP.201106.0009

並列摘要

Background: Leukopenia is a potentially severe side effect of antipsychotic drugs. Clozapine, olanzapine, and chlorpromazine are found to induce leukopenia. Haloperidol-induced leukopenia is occasionally reported. Research are limited to explore hematologic side effects related to the combined use of olanzapine and haloperidol. Case Report: We present a case of a patient with schizophrenia, whose white blood cell count was decreased following receiving a combination of haloperidol and olanzapine, and increased rapidly after discontinuing haloperidol. Conclusion: This case reminds us paying attention to the leukopenic effect of the use of haloperidol or combined antipsychotic drugs. Encountering a patient with a suspected antipsychotics-induced hematologic problem, clinicians need to consider those frequently mentioned offending agents, and to observe its relation with other antipsychotic drugs.

並列關鍵字

leukopenia ； neutropenia ； haloperidol ； olanzapine

參考文獻

Copolov, D,Bell, W,Benson, W(1998).Clozapine treatment in Australia: a review of haematological monitoring.Med J Aust.168,495-7.

Gajwani, P,Tesar, G(2000).Olanzapine-induced neutropenia.Psychosomatics.41,150-1.

Flanagan, RJ,Dunk, L(2008).Haematological toxicity of drugs used in psychiatry.Hum Psychopharmacol.23,27-41.

Ghaznavi, S,Nakic, M,Rao, P(2008).Rechallenging with clozapine following neutropenia: treatment options for refractory schizophrenia.Am J Psychiatry.165,813-8.

Naranjo, CA,Busto, U,Sellers, EM(1982).Difficulties in assessing adverse drug reactions in clinical trials.Prog Neuropsychopharmacol Biol Psychiatry.6,651-7.