An Update on Aspects of Feline Immunodeficiency Virus in Taiwan

台灣地區貓免疫不全病毒基因型資訊的更新

蘇璧伶(Bi-Ling Su) ； 張惠雯(Hui-Wen Chang) ； 林昭南(Chao-Nan Lin) ； 龐飛(Victor Fei Pang) ； 闕玲玲(Ling-Ling Chueh) ； 鄭謙仁(Chian-Ren Jeng)

《臺灣獸醫學雜誌》 35卷3期 (2009/09) Pp. 167-173

https://doi.org/10.7009/TVJ.200909.0167

摘要

為了解台灣地區貓免疫不全病毒基因型的盛行率，於2005至2006年從台灣地區動物收容所以及台大生農學院附屬動物醫院，收集十八個貓免疫不全病毒血清陽性之全血樣品，以PCR增幅env基因片段的V3至V5變異區，將PCR產物進行序列檢測並經核酸及胺基酸之親緣性分析。檢測結果18個樣材有12個為PCR陽性，而其中11個PCR陽性樣材屬於文獻曾報告之C型基因亞型，有一PCR陽性樣材則為台灣地區第一次出現之B型基因亞型。此結果顯示病毒基因型的持續監測有其必要性外，此資訊亦可提供評估貓免疫不全病毒疫苗使用的適當性。

關鍵字

貓免疫不全病毒 ； 基因亞型 ； 台灣地區

並列摘要

To determine the prevalent subtypes of feline immunodeficiency virus (FIV) in the domestic cat population in Taiwan during 2005-2006, the variable V3-V5 region of the envelope (env) gene was amplified by a nested PCR from the samples of whole blood of 18 FIV antibody positive cats. The blood samples were collected from animals in the animal shelters and from clinical cases in the Veterinary Hospital at National Taiwan University. Within the 18 serum positive samples, 12 samples were successful amplified by PCR. After sequencing and phylogenetic analysis of PCR products, 11 samples were clustered within group of subtype C, which is consistent with previous reports. However, the remaining one sample was grouped within subtype B; this is the first time this subtype has been identified in Taiwan. This observation suggests the need of a more comprehensive epidemiological survey before appropriately evaluation of the use of FIV vaccine in Taiwan.

並列關鍵字

feline immunodeficiency virus ； subtype ； Taiwan