This study attempts to explore the counseling strategies and methods of drug abuse among middle school students through a successful case of anti-drug counseling, supplemented by the current literature on drug abuse among middle school students in Taiwan. The results show that there are 32 factors affecting the abuse of middle school students, and anti-drug counseling successful case also completed 30 factors, which reaches more than 90% consistency. And this paper construct a comparative analysis table of drug abuse prevention of middle school students, providing a reference structure for future counselors.