餵食靈芝菌絲體對小鼠體內抗氧化能力之影響

Effects of Ganoderma lucidum Mycelium Feeding on the Antioxidant System in Mice

蕭慧美(Huey-Mei Shaw) ； 夏彩蘭(Choi-Lan Ha)

《中華民國營養學會雜誌》 31卷1期 (2006/03) Pp. 17-23

https://doi.org/10.6691/JCNS.200603_31(1).0003

摘要

Ganoderma (G) lucidum is a traditional medicine in China and has been used in the promotion of health and longevity for thousands of years. The purpose of this study was to examine whether the antioxidative status of tissues was influenced in mice fed diet containing G. lucidum mycelium. In experiment 1, mice were fed AIN-93G diet containing 0 (C), 1% (G1) and 3% (G3) G. lucidum mycelium for 4 weeks, Ingestion of G. lucidum mycelium did not affect the concentration of thiobarbituric acid-reactive substances (TBARS) in the liver, heart, kidney, and lungs as well as the activity of superoxide dismutase (SOD) in the liver. However, the activities of catalase and glutathione peroxidase (GPx) in the liver were significantly increased in the G3 group of mice. In experiment 2, mice were fed the control diet (C) and diet containing 5% G. lucidum mycelium (G5). The concentration of TBARS in the liver was significantly lower in mice fed G. lucidum mycelium. However, the activities of catalase, GPx, and SOD as well as the α-tocopherol contents in the liver were not affected by G. lucidum mycelium. Taken together, the antioxidant effect of G. lucidum mycelium in mice was contributed by enhancing hepatic enzyme activities of catalase and GPx. In addition, lipid peroxidation in the liver was significantly reduced in mice fed diet containing 5% G. lucidum mycelium.

關鍵字

靈芝菌絲體 ； 小鼠 ； 抗氧化酵素 ； TBARS

並列摘要

Ganoderma (G) lucidum is a traditional medicine in China and has been used in the promotion of health and longevity for thousands of years. The purpose of this study was to examine whether the antioxidative status of tissues was influenced in mice fed diet containing G. lucidum mycelium. In experiment 1, mice were fed AIN-93G diet containing 0 (C), 1% (G1) and 3% (G3) G. lucidum mycelium for 4 weeks, Ingestion of G. lucidum mycelium did not affect the concentration of thiobarbituric acid-reactive substances (TBARS) in the liver, heart, kidney, and lungs as well as the activity of superoxide dismutase (SOD) in the liver. However, the activities of catalase and glutathione peroxidase (GPx) in the liver were significantly increased in the G3 group of mice. In experiment 2, mice were fed the control diet (C) and diet containing 5% G. lucidum mycelium (G5). The concentration of TBARS in the liver was significantly lower in mice fed G. lucidum mycelium. However, the activities of catalase, GPx, and SOD as well as the α-tocopherol contents in the liver were not affected by G. lucidum mycelium. Taken together, the antioxidant effect of G. lucidum mycelium in mice was contributed by enhancing hepatic enzyme activities of catalase and GPx. In addition, lipid peroxidation in the liver was significantly reduced in mice fed diet containing 5% G. lucidum mycelium.

並列關鍵字

Ganoderma lucidum mycelium ； mice ； antioxidant enzymes ； TBARS