山楂成分保護PC12細胞之作用

帕金森氏症是一種神經退化性疾病，近年來已有文獻報導巴拉刈與誘導帕金森氏症的產生有關。大鼠腎上腺髓質嗜鉻細胞瘤細胞株（PC12 cell line）在神經分化與細胞死亡研究方面被普遍使用，因此PC12細胞可以作為神經保護作用的研究模式。山楂具備抗癌、抗氧化及抗發炎等多種生理活性，本研究主要是探討山楂成分抑制巴拉刈誘導PC12細胞死亡的作用，結果得知山楂95%乙醇萃取物及山楂酸抑制巴拉刈毒性的能力最佳，可以保護PC12細胞，未來將探討山楂成分保護PC12細胞作用機制，期盼山楂成分能成為神經保護劑。

關鍵字

巴拉刈； PC12細胞；山楂

並列摘要

Parkinson's disease (PD) is a neurodegenerative disorder. In recent years, it has been reported in the literature that paraquat is associated with PD production. The rat adrenal medullary pheochromocytoma cell line (PC12 cell line) is a commonly used model for studies of neural differentiation and cell death. PC12 cells can be used a study model of neuroprotective effect. Crataegus pinnatifida has many physiological activities such as anti-cancer, anti-oxidant and anti-inflammatory effects. This study is mainly to investigate the C. pinnatifida component inhibit paraquat-induced PC12 cell death effect. It is found the 95% ethanolic extract of C. pinnatifida and the crataegolic acid have the best ability to inhibit the toxicity of paraquat. They can protect PC12 cells. In the future, we will research the protective mechanism of action of PC12 cells of the C. pinnatifida component. It is expected that the C. pinnatifida component can become a neuroprotective agent.

並列關鍵字

Paraquat ； PC12 Cell ； Crataegus Pinnatifida

參考文獻

Lin YH, Liu AH, Wu HL, Westenbroek C, Song QL, Yu HM, Ter Horst GJ, Li XJ. Salvianolic acid B, an antioxidant from Salvia miltiorrhiza, prevents Aβ25–35 -induced reduction in BPRP in PC12 cells. Biochem Biophys Res Commun. 2006; 348: 593-599.

Google Scholar

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