The purpose of this study was to explore the relationships among behaviors (substance abuse, health promotion behaviors, and utilization of preventive health service), physiological health (body pain, number of chronic illnesses), and psychological health (depressive symptoms and self-reported health status). The Structural Equation Modeling (SEM) was applied to validate the fitness of conceptual framework and observed data. The results revealed that substance use was negatively correlated with health promotion behaviors. The results of SEM indicated that the citizens who used more frequently preventive health services have a worse status of physiological health. The citizens who adopt less health promoting behaviors and more frequently used preventive health services have a worse status of psychological health. Substance use was not significantly associated with both of physiological and psychological health.