Improvement of Sexual Behavior in Aged Rats by P-Chlorophenylalanine and Methysergide

探討5─羥色胺拮抗物methyser-gide和5─羥胺生成阻斷物PCPA對19-23月齡之年老元整雄鼠之性行為的影響。實驗動物之選擇為：年老雌鼠是陰道抹片呈現持久性角化細胞者，而且性行為試驗證明脊柱前凸商(Lordosis Quotient; LQ)低於50者；年老雄鼠則是性行為中沒有射精(ejaculation)者。性行為試驗前，2至4小時給予腹腔注射PCPA 50mg/kg，或之前4小時給予methyser-gide 3 mg/kg，均可改善年老完整雌鼠之LQ.PCPA或methysergide能改善年老雌鼠之接納性(receptivity)，但不能改善其對雄鼠之求愛行為(approach)。若給予年老完整雄鼠methysergide(3mg/kg)可改善其總騎上次數(total mount fequency)及騎上潛伏期(mount latency)，給予PCPA(每天20MG/KG，連續給予4天)。則可改善總騎上次數及插入潛伏期(intromission latency)。本研究結果加上我們先前研究顯示，年老雌鼠之接納性行為及雄鼠的交配行為之所以低下，與腦中5-羥色胺(serotonin)活性之升高可能有重大相關。

關鍵字

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並列摘要

The effects of methysergide, a serotonin antagonist, and P-chlorophenylala-nine (PCPA),a serotonin synthesis blocker on the sexual behavior of intact old male rats at 19-23 months of age and female rats at 17-18 months of age were studied. Female rats with prolonged vaginal cornification and a lordosis quotient (LQ) of less than 50%, and male rats displaying no ejaculation were selected as experimental animals.The receptivity of aged female rats, but not the approach behavior to males nor proceptivity was improved by PCPA or methysergide. The LQ of intact aged female rats in non-exit tests was improved by the i. p. administration of 50 mg/kg mount latency of intact aged male rats were improved by the adminstration of methysergide (3 mg/kg B. W.), while total mount frequency and intromis-sion latency were improved by the administration of PCPA (20 mg/kg B. W. for 4days).The present results together with the finding from our previous study sug-gest that the increase of serotonin (5-HT) activity per se plays an important role in the decline of receptivity of aged female rats and the copulatory activity of aged male rats.

並列關鍵字

aged ； sexual behavior ； neurotransmitter

國際替代計量

Improvement of Sexual Behavior in Aged Rats by P-Chlorophenylalanine and Methysergide

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