Effects of Amphetamine on Schedule-Induced Polydipsia

Yia-Ping Liu ； Hung-Chin Wang ； Ching-Jiunn Tseng ； Hung-Shan Tang ； Tsai-Hsin Yin ； Che-Se Tung

《The Chinese Journal of Physiology》 48卷4期 (2005/12) Pp. 176-186

並列摘要

A series of experiments examined the effects of amphetamine (AMPH) at various doses administration for different length of time on a schedule-induced polydipsia (SIP) and possible associations with behavioral activation. Two stages of a two-eek AMPH treatment ere introduced with interposed interval of two months. In terms of behavioral activation, AMPH induced a robust depression across stages but with less potency in the second one. As for the SIP performance, the effects manifested qualitative difference in the two stages. For the first stage, there were no differential effects of AMPH on stereotypy intensity during the facultative phase of the inter-rewarding interval. However, AMPH reduced the high frequency of licks in the adjunctive (schedule-induced) phase and increased the low frequency of nose pokes in the terminal (schedule-dependent) phase. In the second stage, AMPH had no effect on the frequency of licking whereas the efficiency of licking and the frequency of nose pokes ere reduced. These results ere interpreted to support the current vie point that the behavior of SIP displaying is relevant to the function of central dopaminergic systems. The results ere further discussed in the considerations of behavioral competition, stress coping strategy, and also the impact of AMPH at different time.

並列關鍵字

amphetamine ； schedule-induced polydipsia ； locomotor activity ； stereotyped behavior ； behavioral competition ； stress coping strategy

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