Advanced stage hepatoma can metastasize to any part of our the body. However, it is rare that oral cavity would be the area of distant metastasis. We describe one patient initially presented with tumors over the oral gingival area, liver and prostate. After serial imaging study, the origin lesion of the tumor was still not very clear. Only by tissue biopsy, was the primary focus concluded to be originated from the liver. In this case report, we emphasize the importance of tissue biopsy in the diagnostic procedure of cancer management, especially in endemic hepatoma areas of Asia.