Antinociceptive and Anti-inflammatory Activity of the Water-soluble Extracts from Leaves of Muntingia calabura

林鳳蘭(Feng-Lang Lin) ； 陳日榮(Jih-Jung Chen) ； 施承典(Cheng-Dean Shih)

《The Chinese Pharmaceutical Journal》 57卷2-6期 (2005/12) Pp. 81-88

https://doi.org/10.7019/CPJ.200512.0081

並列摘要

Muntingia calabura possess several bio-activities and are used in folk medicine of Southeast Asia for relieving of headaches and incipient colds. However, their antinociceptive and anti- inflammatory activity has not been investigated so far. The aim of this study, therefore, was to evaluate the antinociceptive and anti-inflammatory activity of water-soluble extract (WSE) from leaves of M. calabura. The extracts (50, 100, 200, 400 and 800 mg/kg, i.p.) showed significantly reduced the nociception induced by the acetic acid (0.6%) intraperitoneal injection in mice. Furthermore, the antinociceptive effect of the WSE was not significantly antagonized by subcutaneous administration of opioid receptor antagonist, naloxone (5 mg/kg). In the anti-inflammatory study, the WSE (50, 100 and 200 mg/kg, i.p.) exhibited a dose-dependent reduced the carrageenaninduced edema of the hindpaw of adult male rats at 3 h. Acute toxicity was investigated and results were indicated that had no abnormalities were observed in the behavior and lethality by the extract up to 5 g/kg. Together these results indicate that WSE from leaves of M. calabura possess potent antinociceptive and anti-inflammatory activities. In addition, the mechanism of antinociceptive action of the WSE is not related to the opioid system. Therefore, these pharmacological results clearly support traditional folkloric application of M. calaburain in the control and/or treatments of pain, fever, and inflammatory illness.

並列關鍵字

Muntingia calabura ； Tiliaceae ； Antinociceptive ； Anti-inflammatory activity