樟芝菌株(CCRC 93032)發酵液對大鼠28天餵食的毒性作用

Effects of 28-Days' Repeated Oral Administration of the Fermented Extract of Mycelia of Antrodia Comphorata (CCRC 93032) on Rats

林文川(Wen-Chuan Lin) ； 郭淑卿(Shy-Ching Kuo) ； 吳岳文(Yueh-Wern Wu)

《中醫藥雜誌》 12卷4期 (2001/12) Pp. 293-304

https://doi.org/10.6940/JCM.200112_12(4).07

摘要

本實驗主要探討樟芝菌株發酵濃縮液連續經口投予28天對雌、雄大鼠的毒性。樟芝菌株發酵濃縮液的劑量為每天投予1、2或3g/kg。血液學檢查：雄鼠3g/kg組出現平均紅血球容積和平均紅血球血色素量降低的情形。血清生化學檢查：雄鼠3g/kg組血中總蛋白質、葡萄糖、磷濃度及乳酸去氫活性增加，雄鼠2、3g/kg組和雌鼠3g/kg組的血中鉀離子濃度明顯下降。尿液分析：雄和雌鼠2、3g/kg組的尿中排出的鈉和氯離子量增加，雄和雌鼠3g/kg組出現尿蛋白的隻數增加。雄鼠3g/kg組肝臟及腎臟的相對重量增加，但並無實質上的病理組織變化。大鼠連續投予樟芝菌株發酵濃縮液，安全劑量在2g/kg以下。

關鍵字

樟芝菌株體發酵液 ； 急性毒性 ； 28日毒性

並列摘要

Toxicity study was carried out by administering orally daily doses of 1, 2 and 3 g/kg of the fermented extract of mycelia of Antrodia camphorata (FEMAC) to groups of male and female rats for 28 days. Hematological analyses indicated that male rats given 3 g/kg showed significant decreases in mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH). Serum biochemical profiles indicated increased levels of total protein, glucose, phosphorus and activities of lactate dehydrogenase (LDH) were observed in male rats of the 3 g/kg group while decreased serum potassium was observed in male rats given 2 or 3 g/kg as well as female rats given 3 g/kg. Urinalyses showed increased levels in both sodium and chloride ions in both male and female rats of the 2 and 3 g/kg groups, increased incidence of proteinuria in the 3 g/kg groups of both sexes and increase in relative weights of the liver and kidneys in male rats given 3 g/kg although no accompanying histopathological changes were observed. In conclusion, the safety dose of fermented extract of mycelia of Antrodia camphorata (FEMAC) in rats following 28 days of oral administration appeared to be below 2 g/kg.

並列關鍵字

Antrodia camphorata ； Acute toxicity ； 28-day toxicity study