Conjunctival Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma: Report of 6 Cases

結膜之粘膜相關淋巴癌：報告六個案例

李婉如(Wan-Ju Lee) ； 曾順輝(Sung-Huei Tseng) ； 陳盈廷(Ying-Ting Chen) ； 鄭漢春(Hon-Chun Cheng) ； 黃福進(Fu-Chin Huang)

《中華民國眼科醫學會雜誌》 47卷1期 (2008/03) Pp. 40-47

https://doi.org/10.30048/ACTASOS.200803.0006

摘要

目的：原發性結膜淋巴癌發病初期可能被誤診為慢性結膜炎等。吾等提出六例病例並探討其病理組織報告。
方法：蒐集六例病例報告。
結果：計六例病例，年齡介於21至56歲，其中男性四名，女性兩名；所有病人僅結膜被發現有淋巴癌，其他器官並未轉移。三位病人在發病初期被診斷為慢性結膜炎，時間由3至6個月不等，後經由病理切片才確認皆為粘膜相關淋巴組織淋巴瘤(MALT lymphoma)。五位接受局部放射線治療，另一位病患，因個人因素拒絕放射線療法。除了一例雙眼結膜仍有殘存的腫瘤細胞外，其他五位病人目前於眼睛及其他器官均無淋巴癌的存在。
結論：結膜淋巴癌易與慢性結膜炎或其他良性結膜疾病混淆，藉由局部切除及病理切片，可確立診斷並決定其治療方式。

並列摘要

Purpose: Primary conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma can be misdiagnosed as chronic conjunctivitis or other benign diseases. Here, we describe the clinical features and the pathological findings of conjunctival MALT lymphoma in six patients.
Patients and Method: Observational case series. All patients underwent conjunctival biopsy or en block excision, and the specimens were investigated histopathologically.
Results: A total of six patients (4 men, 2 women), aged between 21 and 56 years (mean, 42.7 years), were included in this cohort. Following systemic survey, the conjunctiva tissue was the only involved site in all 6 patients. Three patients (50%) were clinically masqueraded as chronic conjunctivitis 3 to 6 months before the accurate diagnosis was made. Histopathologic examinations showed a low-grade MALT B-cell lymphoma in all patients. Except for one refused any intervention, the other five patients received radiation therapy. Because of absence of the systemic involvement, none of the patients had chemotherapy. During a mean follow-up period of 25.5 months, five of them had no recurrence in the conjunctiva or any other organs but one (case 6) had residual tumors in both eyes though after some fractions of radiation therapy.
Conclusion: Although rare, the conjunctival MALT lymphoma may clinically mimic chronic conjunctivitis and should be included in the differential list of prolonged conjunctival inflammation. A biopsy of the conjunctival lesion would help confirm the accurate diagnosis of this multi-systemic disease.

並列關鍵字

mucosa-associated lymphoid tissue MALT lymphoma ； biopsy