Macau is accelerating a smart healthcare system under the construction of a smart city. Chronic illnesses seriously threat the health of residents due to high morbidity, high disability, high mortality and high burden to health system. Problems caused by inappropriate health management for patients with chronic illnesses in Macau are also a concern. Healthcare organizations and community institutions at medium-level can assist and serve patients with chronic illnesses and their families at micro-level to perform effective health management by making the most use of the smart healthcare system. The effectiveness of the smart healthcare system only can be achieved through legislation, leadership, cooperation, policy integration, financial support, and human resources distribution as well as appropriate management.