Urinary tract stone or calculi is a common disease with a prevalence rate of about 9.6% in Taiwan, and men are affected more frequently than women. The treatment for the urolithiasis could differ largely depending on the presenting symptoms. If asymptomatic, patients with urolithiasis need only conservative therapy. On the other hand, urinary calculi could induce unbearable pain leading to incapacitation, then surgical intervention would be required. In severe cases or if leave untreated, urolithiasis could lead to urinary tract obstruction, hydronephrosis, acute kidney injury, urinary tract infection and sepsis. Even the disease had been cured, the high recurrence rate should be noted. It is difficult to predict when renal colic will attack and cause in-flight incapacitation, thus urinary tract stones are of major flight safety concern. Pilots with urinary tract stones should be examined to evaluate underlying causes and treated. For those with high risk of obstruction, intervention is recommended. Waiver may be granted if aeromedical evaluation suggest low risk of colic attack.