The purpose of such industry-university cooperation is to guide Scholarly research energy to proceeded practice applicability by industry. How to make use of result of industry-university cooperation with regard to technology licensing and commercialization have become more critical. This study used the questionnaires to explore the relation between industry-university cooperation and practice applicability on innovation performance; moreover, PLS was used to verify the models. The results suggestions in this study include how to promote the limited resource and strategy development in higher education.