Due to special climate environment and geographical location of Taiwan, typhoons, torrential rains, and earthquakes often cause serious injury and loss of people's lives and property. All sectors of the community have always been very concerned about disasters. During the period from 1998 to 2006, the National Science and Technology Program for Hazards Mitigation (NAPHM) sponsored by the National Science Council has greatly improved the level of disaster prevention R&D in Taiwan, and helped to establish a proper disaster prevention and response system, improve the efficiency of practical operations, and strengthen the overall disaster resistance capability, which has been recognized by the publics. This paper presents the formation, processes in planning and execution, and results of implementation and extension of the Program. It is hoped that this experience can be useful for reference in future work of similar nature.