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摘要


肛門惡性黑色素瘤以少見、癒後不佳著稱,約佔肛門直腸惡性腫瘤的百分之一。黑色素癌在整個消化道中,好發的位置以肛門最為常見。在全身的黑色素瘤中,肛門直腸黑色素瘤所佔之比例約為百分之0.4至百分之1.6之間,位居第三,排名於皮膚及視網膜之後。過去有關的文獻記載稀少,本病例呈現完整的病史及各種典型的臨床表徵。在治療方面,因過去均以少數個案病例序列報告為主,對於決定適當的治療方式實屬困難。外科手術介入的角色迄今沒有定論,所有的手術方式都被認為無法完全根治。因此放射治療、化學治療、免疫治療、抑或是標靶治療都應考慮加入治療計畫之中,以改善病患的存活率。

並列摘要


Anal malignant melanoma is notorious for its poor outcomes, accounting for approximately 1% of all anorectal malignancies. In the entire alimentary tract, the disease most frequently originates in the anal canal. Further, as a percentage of all melanomas, 0.4% to 1.6% arise in the anorectal region. Consequently, it is no surprise that, other than the skin and the retina, the anal canal is the most common site of melanoma. Here we presented a case with intact clinical manifestations and comprehensive treatment. Because anal malignant melanoma cases are quite rare, few case series have been reported in the literature, which further compounds the difficulties inherent in treatment of this disease. Additionally, the decision to surgically intervene in cases of malignant melanoma remains controversial, in part because complete remission is hard to achieve with any surgical method. Thus, radiotherapy, chemotherapy, immunotherapy and target therapy should first be considered in the treatment of anorectal melanoma to help improve overall survival rate.

延伸閱讀


  • 蘇仁沛、許瑞昇、馬佑鈞(2020)。肛腸惡性黑色素瘤-病例報告中華放射線技術學雜誌44(2),90-94。https://www.airitilibrary.com/Article/Detail?DocID=16849418-202006-202011020008-202011020008-90-94
  • 侯平康、吳愛卿(1979)。結膜惡性黑色素瘤中華民國眼科醫學會雜誌18(),52-59。https://doi.org/10.30048/ACTASOS.197905.0010
  • Chen, S. B., & Lee, W. J. (2009). 肛門之Paget's disease:病例報告. 中華民國大腸直腸外科醫學會雜誌, 20(3), 69-73. https://doi.org/10.6312/SCRSTW.2009.20(3).09720
  • Hsieh, C. C., Tsai, M. H., Jan, C. I., Tsai, C. H., & Chong, N. S. (2006). 直腸惡性黑色素細胞瘤: 病例報告. 放射治療與腫瘤學, 13(3), 225-229. https://doi.org/10.6316/TRO/200613(3)225
  • 胡偉敏、莊其穆、趙灌中、王鵬惠(2006)。惡性陰道黑色素細胞瘤中華民國婦癌醫學雜誌(2006年2),11-13。https://doi.org/10.7010/JGO.200610.0011

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