多環芳香烴化物暴露對煉焦勞工氧化傷害評估研究

Oxidative Stress Evaluation for Polycyclic Aromatic Hydrocarbons Exposed Coke-Oven Workers

潘致弘(Chih-Hong Pan) ； 賴錦皇(Ching-Huang Lai) ； 吳明蒼(Ming-Tsang Wu)

《勞動及職業安全衛生研究季刊》 23卷3期 (2015/09) Pp. 290-310

摘要

煉焦爐勞工長期暴露煉焦爐排放物，其中對健康影響最為嚴重者為多環芳香烴化物（PAHs），PAH除了會導致肺癌等呼吸道癌症之外，亦有可能導致泌尿系統癌症、皮膚癌與神經系統損失等疾病，本研究針對台灣某鋼鐵公司煉焦作業勞工進行橫斷面流行病學研究，由問卷調查區分為爐頂煉焦勞工（高暴露組，N=110）、爐側煉焦勞工（低暴露組，N=182）。暴露偵測包括16種PAHs，及以尿液中的1-羥基焦腦油（1-OHP）作為PAH的內在劑量暴露指標，並以尿液8-羥基-2-去氧鳥嘌呤核甘（8-OHdG）作為DNA氧化傷害指標。資料分析以線性混合效應迴歸模式評估員工之尿液中8-OHdG與1-OHP的相關性。研究結果顯示，爐頂煉焦勞工個人採樣空氣中之PAHs濃度、尿液中8-OHdG、1-OHP濃度皆顯著高於爐側煉焦勞工。以線性混合效應迴歸模式分析顯示：在校正其他干擾因子後，尿液中1-OHP、爐頂煉焦工作為尿液中8-OHdG的二個顯著影響因子，尿液中1-OHP、爐頂煉焦工作為PAHs暴露造成DNA氧化傷害的良好預測因子；本研究結果並指出煉焦勞工的DNA氧化傷害與暴露PAHs有顯著相關。

關鍵字

多環芳香烴化物 ； 煉焦勞工 ； 尿液中1-羥基焦腦油 ； 尿液中8-羥基-2-去氧鳥嘌呤核甘

並列摘要

Coke oven workers have long-term been exposed to coke oven emissions (COEs). PAHs are important components of COEs that caused most seriously health effects among coke oven workers. Long-term exposure to PAH concentrations has been associated with lung cancer, respiratory cancer, urinary system cancer, skin cancer, and neurological diseases. This study conducted a cross-sectional epidemiology research for coke oven workers in a steel company in Taiwan. Based on job titles obtained from responses to the questionnaire survey, the coke oven workers were classified into two groups, including topside-oven workers (high exposure group, N=110), and side-oven workers (low exposure group, N=182). We quantified human subject exposure to 16 PAHs by using personal dosimetry. Urinary 1-hydroxypyrene (1-OHP) was used as an internal dose of exposure to PAHs, and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was used as an oxidative DNA damage marker. The relationship between workers' 8-OHdG and 1-OHP levels was estimated using linear mixedeffects models. Airborne PAHs levels in topside-oven workers significantly exceeded those in sideoven workers. The topside-oven workers' geometric mean levels of urinary 8-OHdGand 1-OHP were significantly higher than those of side-oven workers, respectively. Urinary 1-OHP level, and work in topside-oven, gender were two significant predictors of urinary 8-OHdG levels, after adjustments are made for covariates. Oxidative DNA damage was associated with exposure of coke oven workers to PAHs.

並列關鍵字

Polycyclic aromatic hydrocarbons ； Coke oven workers ； Urinary 1-hydroxypyrene ； Urinary 8-hydroxy-2'-deoxyguanosine

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