金奈米粒子於生物醫學上的應用

Biomedicial Applications of Gold Nanoparticles

李映瑩(Ying-Ying Li) ； 蔡宗霖(Tsung-Lin Tsai) ； 謝達斌(Dar-Bin Shieh)

《化學》 68卷1期 (2010/03) Pp. 11-20

https://doi.org/10.6623/chem.2010002

摘要

在許多金屬材料中，黃金是最早開始被廣泛研究的膠體金屬。由於製備方法簡單與生物相容性高等許多優點，金奈米粒子被視為最容易應用於生物體的材質，因此許多有關金奈米粒子結合生物分 子的研究也紛紛出現，其中在生物晶片與感測器的應用上更是頻繁，依其本身具有之特殊光學性質、結構上及官能化後可與生物分子相容之優點，使金奈米粒子於生物醫學上之研究與發展逐年增加。本文主要分成三大部份來探討生物醫學上的應用：未修飾之金奈米粒子、結合DNA及蛋白質之金奈米粒子。我們預期金奈米粒子在生物檢測與臨床治療的領域上，會是一個很好的生物標靶材料。

關鍵字

金奈米粒子 ； 生物檢測 ； 生物標靶材料

並列摘要

In numerous nanomaterials, gold has been extensively developed as colloidal metal since early times in Europe. Due to relative simple preparation and high biocompatibility, gold nanoparticle is the most widely applied nanomaterials in biomedicine such as bio-chips, biosensing and bio-imaging using biomolecule- gold nanoparticle conjugates. These include ultrasensitive molecular-molecular interaction detection using SERS (Surface Enhanced Raman Spectroscopy) in vitro and vivo. Gold nanoparticles have been successfully used as a therapy for rheumatoid arthritis (RA) and for cancer treatment in disease animal models in recent years. Gold nanoparticles applied for tumor targeting with surface modification of peptide ligands or antibodies have been reported and thus may enable simultaneous diagnostics and therapeutics in one single platform-the theranotics concept. In this review we will introduce the various biomedical application based on native gold nanoparticles and their different modifications (DNA, peptide and enzyme). The potential for gold colloid and its derived functional nanoparticles is anticipated to play a critical role in future medicine.

並列關鍵字

Gold nanoparticles ； Bio-medical applications ； Surface modification