使用質譜儀找尋鄰苯二甲酸酯類之暴露標記

Exposure Marker Discovery of Phthalates Using Mass Spectrometry

許仁譯(Jen-Yi Hsu) ； 石佳隴(Chia-Lang Shih) ； 曹嘉云(Chia-Yun Tsao) ； 廖寶琦(Pao-Chi Liao)

《化學》 74卷3期 (2016/09) Pp. 223-234

https://doi.org/10.6623/chem.2016021

摘要

鄰苯二甲酸酯類為在工業中被廣泛使用的化學品，暴露這些物質對人體健康所造成的影響受到大家的重視。鄰苯二甲酸酯類的尿液代謝物可以被測量且作為暴露的標記用來評估經由不同途徑和吸收方式進入人體的鄰苯二甲酸酯類。此篇文章將會對鄰苯二甲酸酯類，如：di-methyl phthalate (DMP)，di-ethyl phthalate (DEP)，di-butyl phthalate (DBP)，benzylbutylphthalate (BBP)，di-(2-ethylhexyl)phthalate(DEHP)，di-(2-Propylheptyl) phthalate (DPHP)，di-iso-nonylphthalate (DINP)，di-n-octyl phthalate (DnOP)and di-iso-decyl phthalate (DIDP) 作為暴露與風險評估的暴露標記進行回顧，並介紹三種代謝體數據處理分析方法，其可於高解析質譜儀數據結合做為找尋尿液中化合物暴露標記的工具。

關鍵字

鄰苯二甲酸酯類 ； 生物監測 ； 代謝體學

並列摘要

Phthalates are chemicals widely used in industry and the consequences on human health caused by exposure to these agents are of significant interest currently. The urinary metabolites of phthalates can be measured and used as exposure markers for the assessment of the actual internal contamination of phthalates coming from different sources and absorbed by various ways. The purpose of this paper is to review the exposure markers for exposure and risk assessment of phthalates such as di-methyl phthalate (DMP), di-ethyl phthalate (DEP), di-butyl phthalate (DBP), benzylbutylphthalate (BBP), di-(2-ethylhexyl)phthalate (DEHP), di-(2-Propylheptyl) phthalate (DPHP), di-iso-nonylphthalate (DINP), di-n-octyl phthalate (DnOP) and di-iso-decyl phthalate (DIDP), andintroductionof the analytical approach of three metabolomics data processing approaches that canbe used for chemical exposure marker discovery in urine with high-resolution mass spectrometry (HRMS) data.

並列關鍵字

Phthalates ； Biomonitoring ； Metabolomics