Ever since Buddhism was transmitted from India to other parts of the globe, it has had to find its way through a seemingly endless array of host cultures. As the world's largest Buddhist order, Fo Guang Shan has successfully taken root in some 200 major cities across the Five Continents. How has Humanistic Buddhism as advocated by Fo Guang Shan's founder - Venerable Master Hsing Yun, acculturated to a wide range of cultural locations across the world? This paper aims to assess the progress and acculturation of FGS, and discuss the factors of success and failures in terms of its acculturation strategies, changes in the approaches of Dharma propagation, and acculturative stress experienced.