During the winter, the haze weather in Henan Province frequently appears, the main pollutant that causes the haze weather is PM2.5. This article is to explore the economic and social influencing factors of PM2.5 in Henan Province. According to the geographical distribution of each prefecture-level city in Henan Province, five cities (Zhengzhou, Luoyang, Anyang, Shangqiu, Xinyang) are selected as the research objects, and the economic and social driving factors of the annual average concentration of PM2.5 in each city is analyzed based on the gray correlation model. This article founds that although there are regional differences in the distribution of PM2.5 concentration in Henan Province, the PM2.5 concentration of the five selected cities is closely related to industrial structure, urbanization and energy consumption, is unrelated to the number of civilian vehicles and traffic. Therefore, Henan Province's next air pollution prevention measures should focus on the upgrading of industrial structure and urbanization.