At present, my country is developing towards green, diversified and low-carbon in the concept of national energy strategy, and pay more attention to the safety of energy supply and the protection of the ecological environment. Liquefied natural gas (LNG) is a relatively advanced energy source. As an efficient and low-carbon clean energy, it gradually dominates the world's energy system, and my country's demand for natural gas is increasing. As a clean energy source, LNG has a very serious accident once it leaks. In order to reduce and prevent safety accidents during LNG transportation, this article will conduct research and analysis on the risk factors of LNG marine transportation, and use the comprehensive evaluation method (FSA) to study the risk factors from the four aspects of "man-machine-environment-pipe". At the same time, based on the basic theory of the fault tree analysis method, a fault tree model of LNG marine transportation leakage accidents is established. Using the qualitative analysis method, the minimum cut set, minimum diameter set of the entire model and the structural importance coefficient of each basic event are calculated. Finally, based on the risk analysis content, corresponding control and preventive measures are proposed to ensure that LNG is transported at sea safety.