During the novel coronavirus pneumonia epidemic prevention and control period, in order to stop the epidemic spreading to the campus and ensure the safety of teachers and students, the Ministry of education proposed a new educational measure of "stopping classes and not stopping teaching, stopping classes and not stopping learning". After the epidemic, how to integrate the online classroom with the real offline classroom has become a topic of concern for many teachers. In this paper, based on the characteristics of medical functional experiment course and the online open course learning platform, combined with the medical virtual simulation experiment teaching platform, we discussed how to carry out online and offline Hybrid Teaching in medical functional experiment course, so as to stimulate students' enthusiasm in learning functional experiment course and improve the teaching effect of experimental course, and to provide reference for teaching research in the post epidemic era.