Dispatch release is one of the most important posts in the airline operation center. The dispatch and release of flights involves NOTAMs, weather, maintenance, crew qualification, etc. In order to prevent emergencies during operation, the dispatch and release of each flight shall meet the operation standards specified by the Civil Aviation Administration of China. If a flight has no alternate aerodrome available due to weather or other reasons, it cannot be released. This paper takes a flight with no available alternate airport as an example to analyze the factors that flight dispatchers need to consider, which can improve the business level of flight dispatchers.