- 學位論文
新陳代謝症候群風險指標與微量營養素攝取量相關性的探討
Association between metabolic risk factors and micro-nutrients intake in metabolic syndromes
摘要
很多研究已經證明飲食中巨量營養素的攝取包括:碳水化合物、蛋白質和脂肪在病理學上與肥胖症、新陳代謝症候群或者發展成第二型糖尿病有強烈相關。反之，微量元素像礦物質或者維生素並不在攝取的食物當中提供熱量，因此生理在上所扮演的角色被長時間被忽視。最近的證據顯示這些礦物質和維生素實際佔有體內自動平衡管理重要的角色，並且可能扮演有助於在新陳代謝症候群中的角色。例如:最豐富細胞內的二價的陽離子鎂，在身體已經參與超過300代謝，血中低濃度的鎂已經被證實與新陳代謝症候群、胰島素阻抗性和第二型糖尿病有著強烈相關性。與此類似的維生素D，以前一直認為是與骨頭有關的重要維生素，現在被證明可作一個rennin gene的負調控。血清濃度維生素D減少會促使腎素-血管收縮素系統和胰島素阻抗性作用。因此是這項研究的目的探討飲食中礦物質及維生素攝取量與葡萄糖耐量異常或第二型糖尿病相關性。共有358受試者參與國立台灣大學醫學院附設醫院雲林分院對民眾健康檢查，在2006年2月到2007年4月之間，收集在這項研究過程中受試。我們的結果證明在新陳代謝症候群中收縮血壓 ( SBP ) 中指出與飲食中鈣和維生素B6的攝取有關，而舒張血壓 ( DBP ) 與鈣及維生素B1、B2、B5 和B6攝取有關。對於血糖濃度來說，我們的結果證明飲食中的纖維、維生素E 攝取有相當關係。總膽固醇濃度與維生素B12攝取有關。高密度脂蛋白 ( HDL ) 以及低密度脂蛋白 ( LDL ) 血清濃度兩者則與鋅的攝取量有關。另外在高密度脂蛋白 ( HDL ) 的濃度與維生素B5 和B6攝取有關，而與低密度脂蛋白 ( LDL ) 與維生素B12 有相關。在本文中我們的數據顯示出礦物質和維生素有足夠的攝取量是可以預防新陳代謝症候群的發展。
並列摘要
Many studies have proved that the dietary intake of macronutrientsincluding carbohydrate, protein and lipid is strongly related to the pathological development of obesity, metabolic syndromes or type 2 diabetes mellitus. On the contrary micronutrients such as minerals or vitamins do not provide energy in the food, and their physiological roles have therefore long been neglected. Recent evidences have shown that these minerals and vitamins actually play important roles in regulating energy homeostasis, and may consequently contribute to the status of metabolic syndromes. For example, the second most abundant intracellular divalent cation, magnesium, has involved in more than 300 metabolic reactions in the body, and lower serum concentration of magnesium has been proved to be strongly associated with the metabolic syndrome, insulin resistance, and type 2 diabetes mellitus. Similarly, vitamin D, previously regarded as bone-related vitamin, is now proved to be a negative regulator of the rennin gene. Decreased vitamin D serum level may contribute the rennin-angiotensin system, and insulin resistance. It is therefore the aim of this study to evaluate the relationship between the dietary intake of the minerals and vitamins of the subjects with impaired glucose tolerance or type 2 diabetes mellitus. A total of 358 patients who visited National Taiwan University Hospital Yun-Lin Branch for general Health check-up, between February 2006 and April 2007, have been recruited in this study. Our results demonstrated that, within the indicators of metabolic syndrome, systolic blood pressure ( SBP ) is significantly related to the dietary intake of calcium and vitamin B6, while diastolic blood pressure ( DBP ) is significantly related to the intake volume of calcium, vitamins B1, B2, B5, and B6. For blood sugar level, our results demonstrated that dietary fiber, fat, vitamin E are significantly associated. Total cholesterol was associated with the intake of vitamin B12. Both high-density-lipoprotein ( HDL ) and low-density-lipoprotein ( LDL ) serum levels were associated with the intake volume of zinc. In addition, the level of HDL was associated with the intake volume of vitamins B5 and B6, while LDL was with those of vitamin B12.In summary, our data indicated that sufficient dietary intake of minerals and itamins may prevent the development of metabolic syndromes.
參考文獻
延伸閱讀
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