- 學位論文
磷酸鈣骨水泥添加聚麩胺酸之複合材料製備分析及以注射方式用於 隆鼻之研究
Injectable Calcium Phosphate Cement Incorporated with γ-PGA Particle For Rhinoplasty
摘要
過去隆鼻主要是為了矯正畸形、改善鼻功能，而現今美學觀念抬頭，隆鼻是為了增強外觀。新型隆鼻使用注射方式將材料注入患者鼻背、鼻尖，並在患者鼻部放一模具加以定形，填入材料固化後即完成塑形。注射優點為最小侵入性外科手術、操作簡便、修復時間短、不會留下疤痕，可降低患者心理恐懼。 本實驗主要探討磷酸鈣骨水泥添加不同比例聚麩胺酸的氫氧機磷灰石相轉變率、微觀結構、注射性質、流變性質、固化時間、降解情形、生物相容性。實驗結果顯示，聚麩胺酸1%有最高的氫氧機磷灰石相轉變率，最短的成膠、固化時間，注射性質達臨床上使用門檻，聚麩胺酸降解後系統保持穩定，為毒性很低的材料且具生物適應性。由上述結果可顯示，本實驗開發出可注射式、可生物分解、可自體固化、具有骨誘導性的新型骨水泥，極具發展潛力應用於隆鼻，可望未來提供給不敢開刀之患者另一種新選擇。
並列摘要
Rhinoplasty was mainly performed to correct traumatic and improve nasal functionality. Today, it is gaining popularity for esthetic enhancement. A novel technique for rhinoplastry is operated by injecting material into patient’s nasal dorsum or nasal tip and place a removable mold for fixation. It’s a minimally invasive surgical procedure and has advantages of easy to handle, no visible skin incisions, reducing repair time and decreasing patient’s fear. This study is focused on discussing the influences of three different ratios of γ-glutamic acid in CPC on HAP conversion, micro structure, injection, rheology, setting time, degradation and biocompatibility. Results showed the optimum ratio of γ-PGA in CPC for highest HAP conversion, shortest gelation and setting time and 85% clinical acceptable injectability is 1%. The system remains stable after degradable test and the results of cytotoxicity assays showed no harmful to the cell differentiation and proliferation. In summary, this bone cement composite possesses great developing potential to be applied on rhinoplasty and can be a new choice for patients who are afraid of operation.