以快速微製程開發之三維流體邏輯裝置及整合技術

3D fluidic logic devices by rapid micro-fabrication and integration

楊祥至(Hsiang-Chih Yang)

指導教授 ： 蘇育全

國立清華大學/原子科學院/工程與系統科學系/碩士(2019年)

摘要

近年來，隨著生醫與化學領域的發展，微流道裝置的可攜性與積體整合成為了非常重要的開發方向。然而裝置在積體整合的過程中，體積龐大且數量眾多的外部控制(Off-chip control)限制了裝置微型化的可行性。因此許多研究人員嘗試以裝置內部整合元件的邏輯控制(On-chip control)取代外部控制來解決微型化的問題。要實現流體系統的整合，最大的挑戰在於具氣壓增益效果的流體元件之開發是非常困難的。以現有方法(軟微影製程等等)製造的裝置更面臨昂貴、耗時與人力加工的問題。本論文將提出以先進DLP光固化3D列印技術製造的新型氣壓增益閥實現多層級的邏輯元件整合。以整合系統取代外部控制並應用於微流體裝置。
新型氣壓增益閥具有類似電晶體訊號增益與開關的功能，以輸入氣壓控制腔體之間具Bump構造的膈膜切換輸出的開關狀態，目前已經可以達到~200%氣壓增益。接著利用增益閥優異的性能完成了以正壓為訊號源的多種基本邏輯閘。透過不同邏輯閘的整合，就可以產生多元且大量的平行邏輯訊號，減少流體系統對外部控制的需求。對於積體化的流體系統，元件的切換速度是非常重要的參數，透過多層級的系統整合，我們驗證了元件最大切換頻率可達11 Hz。更進一步的實現了以整合電路取代傳統微幫浦的外部輸入源，實現打水速率6.62 ul /min且僅需單一外部輸入的新型微幫浦。
這是第一個以DLP光固化3D列印技術開發的一體成型三維流體邏輯元件整合系統，便宜、快速以及自動化的製程有利於未來流體系統積體化的發展。以正壓為輸入源的特性使其可以被應用於許多類型的裝置，例如微流體分析晶片的可程式化輸入控制器，或是氣動軟性機器人的氣壓源控制器等，是非常重要的研究貢獻。

關鍵字

光固化三維列印 ； 微流體 ； 微流體整合元件 ； 氣壓增益閥

並列摘要

In recent years, with the development of biomedicine and chemistry, to realize portable and powerful microfluidic systems is more important. However, the bulky and numerous off-chip control device (solenoid valve, Air compressor etc.) would limit the feasibility of miniaturization of microfluidic device. Therefore, many researchers have tried to solve the problem of miniaturization by replacing the external hardware with the on-chip integration of microfluidic logic elements. To realize the integration of microfluidic system, The hardest challenge is development of a mechanical device with pressure gain analogous the voltage gain of a transistor. Here we present a new type of pneumatic gain valves that can be 3D printed and integrated to realize multistage logic systems. They can replace many bulky external hardware, and control a variety of microsystems.
New type of pressure gain valve is analogous to transistor that has a function of signal gain and switching output status. By tailoring the bump geometry, a 200% pressure gain (i.e. the ratio between output and input pressures) have been achieved. As such, the output of one logic stage can be boosted to serve as the input for next stage. 3D integrated digital controllers with multiple logic stages cascaded in series that working frequency can achieve 11 Hz and variety of logic gate have been successfully demonstrated. Furthermore, we developed a new type of peristaltic pump that is composed with integrated fluidic circuit which function as reducing external input and the pump rate can achieve 6.62 µl /min.

並列關鍵字

3D printing ； microfluidic ； microfluidic integrated component ； pressure gain valve

參考文獻

1. A. Manz. N, Graber. H and M. Widmer, ” Miniaturized total chemical analysis systems: A novel concept for chemical sensing”, Sensor and Actuator B, 1990, 1, 244.

2. A. Manz, Unger, H. P. Chou, T. Thorsen, A. Scherer and S. R. Quake, “Monolithic Micro-fabricated Valves and Pumps by Multilayer Soft Lithography”, SCIENCE, 2000, 288, 113.

3. Microfluidic devices for modeling cell–cell and particle–cell interactions in the microvasculature - Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/Fabrication-Process-of-PDMS-devices-by-soft-lithography-a-Spin-coating-of-photoresist_fig1_51496619 [accessed 14 Jul, 2019].

4. 劉亮巖，「可程式化數位壓力控制器之設計與三維列印」，國立清華大學工科所，碩士論文，中華民國106年。

5. Hwang, Y. et al, ”Capillary flow in PDMS cylindrical microfluidic channel using 3-d printed mold”, Journal of Microelectromechanical Systems, 2016, 25, 238.