In the clock network synthesis, the power consumption of the clock mesh is higher than the power consumption of the clock tree, and non-uniform clock mesh and clock gating are two commonly techniques to reduce dynamic power. Non-uniform clock mesh can reduce wire length, and clock gating can reduce dynamic power consumption. In this paper, under both the enable timing constraint and clock skew constraint, we propose a methodology to reduce the switching capacitance. In comparison with no clock gating in the non-uniform clock mesh and with clock gating in the uniform clock mesh is applied, experimental results show that our methodology can get feasible solution and reduce the switching capacitance efficiently.