台灣產粗榧屬台灣粗榧根部之化學成份研究

Studies on the Chemical Components of the root of Cephalotaxus wilsoniana Hayata

張朝淵(Chao-yuan Chang)

指導教授 ： 錢偉鈞

朝陽科技大學/理工學院/應用化學系/碩士(2012年)

摘要

台灣粗榧(（Cephalotaxus wilsoniana Hayata），又稱為威氏粗榧或台灣三尖杉，為粗榧科(Cephalotaxaceae)，粗榧屬(Cephalotaxus)的植物，是台灣特有種的稞子植物。
台灣粗榧(（Cephalotaxus wilsoniana Hayata）根部，經室溫蔭乾、粉碎後以甲醇浸泡3次，每次7日，過濾後浸泡液減壓濃縮得一甲醇粗萃物，然後利用管柱色層分析、薄層層析、再結晶等方法分離純化之，利用光譜分析鑑定其化學結構，共得9個化合物。
所分離到的化合物有三個固醇類β-sitosterone ( 1 )、β-sitosterol ( 2 ) 、Stigmasterol ( 3 )，一個直鏈類：Fatty acid ( 4 )，四個芳香族類：4-hydroxybenzaldehyde ( 5 )、4-hydroxy-3,5-dimethoxy benzoic acid( 6 ) Benzoic acid ( 7 )、4-hydroxycinnamic acid ( 8 )，及一個雙黃酮類Robustaflavone ( 9 )。其中Robustaflavone及為首次於台灣粗榧中發現。

關鍵字

粗榧屬 ； 台灣三尖杉 ； 粗榧科

並列摘要

Cephalotaxus wilsoniana Hayata was Formosan original gymnosperm. The dried stems of Cephalotaxus wilsoniana Hayata were ground and soaked in methanol at ambient temperature. The solution was drained after a 7 day soak period, the residue stems were re-soaked in methanol for 7 days, and the solution re-drained at three times during a 21 day period. The filtered methanolic extracts were combined and concentrated under reduced pressure to a viscous residue. The residue was further isolated and purified by column chromatography, thin layer chromatography and re-crystallization. Nine constituents were found and their structures were established on the basis of spectral analysis and comparison with the literature data. These compounds included three sterols：β-sitosterone ( 1 )、β-sitosterol ( 2 ) 、Stigmasterol ( 3 ) ; one Fatty acid ( 4 ) ；four aromatics：4-hydroxybenzaldehyde ( 5 )、4-hydroxy-3,5-dimethoxy benzoic acid( 6 )、 Benzoic acid ( 7 )、4-hydroxycinnamic acid ( 8 )；one flavonoid： Robustaflavone ( 9 ). Among the isolated compounds, Robustaflavone ( 9 ) were the first reported in Cephalotaxus wilsoniana Hayata.

並列關鍵字

Cephalotaxaceae ； Cephalotaxus ； Cephalotaxus wilsoniana Hayata

參考文獻

1.台灣植物誌編輯委員會編著, Flora of Taiwan,現代關係出版社, 1996,Ⅰ.506.

Phytochemistry, 1972, 11, 3317-3320.

5. R. G. Powell, K. L. Mikolojczak, Phytochemistry, 1973, 12, 2987-2991.

8. W. Lin, R. T. Chen and Z. Xue, Acta pharmaceutica sinica, 1985, 20,

14. Y. H. Kuo, C. H. Lin, S. Y. Hwang, Y. C. Shen, Y. L. Lee and S. Y. Li, Chem. Pharm. Bull., 2000, 48, 440-441.