慢性腎臟病病人的心血管風險評估

Cardiovascular Risk Prediction in Patient With Chronic Kidney Disease

王智賢(Chih-Hsien Wang) ； 徐邦治(Bang-Gee Hsu)

《腎臟與透析》 32卷2期 (2020/06) Pp. 65-69

https://doi.org/10.6340/KD.202006_32(2).0003

摘要

心血管疾病是慢性腎臟病（chronic kidney disease, CKD）患者的重要併發症。最近的大型研究指出關鍵的CKD測量指標（腎絲球過濾率和白蛋白尿）超越傳統的心血管危險因子，可改善心血管疾病風險評估，並且可在不同疾病患者中重現。另外，最近的一些研究表明，使用除血清肌酸酐（creatinine）以外的其他過濾標記物，像血清胱蛋白（cystatin C）和β2-微球蛋白（β2-microglobulin）可以改善心血管疾病的風險評估。另反映心血管系統病理生理過程的測量，例如冠狀動脈鈣化評分（coronary artery calcium score）或高敏感性心臟肌鈣蛋白T（high-sensitivity cardiac troponin T），在CKD病人患者中也可能有幫助。在本文中，我們將探討CKD病人的心血管風險評估。

關鍵字

慢性腎臟病 ； 心血管疾病 ； 風險評估

並列摘要

Cardiovascular disease is an important complication for patients with chronic kidney disease (CKD). Recent large meta-analysis have shown that key CKD measures (estimated glomerular filtration rate and albuminuria) improve cardiovascular risk prediction beyond traditional risk factors and reproducible across different sets of patients. In addition, several recent studies have shown that the use of filtration markers other than serum creatinine, cystatin C, and β2-microglobulin can improve cardiovascular risk prediction. Measures reflecting pathophysiological processes in the cardiovascular system, such as coronary artery calcium score or high-sensitivity cardiac troponin T, can be useful in CKD populations. In this paper, we will summarize these aspects of cardiovascular risk prediction in patients with CKD.

並列關鍵字

chronic kidney disease ； cardiovascular disease ； risk prediction