Due to recent growing attention to patient medication safety, there has been greater interest in educating nurses on the safe administration of oral medications. This purpose of this study was to improve the completion rate of nurse-led course on the safe oral administration of medications by nurses. The completion rate had dropped to four percent. The reasons for this low rate were an absence of common drug models in the units, an absence of medical teaching templates, frequent replacement of new unfamiliar drugs, and a lack of familiarity with the ”pharmacopoeia operation system.” Our findings led us to create a graphic drug handbook and entity models, educate the nursing staff on how to use the information system queries on drug-related information, and set up drug healthcare teaching models and other measures. These changes increased the course completion rate to sixty-seven percent.