Persistent fatigue is a symptom that cannot be ignored after COVID-19 infection, it may affect the quality of life, even accompanied with mood disorders or impaired cognition. There are several mechanisms that could lead to persistent fatigue, which need to be further differentiated. We also postulate the pathophysiology of COVID-19 disease, that is, dryness damaging the lung and spleen deficiency with dampness encumbrance. Through the efforts of traditional Chinese medicine, the patients may show better outcomes.