Esophageal stricture associated with the use of a nasogastric tube is very uncommon, and has been reported only rarely in the literature so far. We report a patient who had an indwelling nasogastric tube for more than 2 months and developed severe distal esophageal stricture one month after the tube was removed. The possibility of such a serious complication associated with the use of nasogastric tube in routine clinical procedure reminds us that there may be alternative means, such as percutaneous endoscopic gastrostomy, to avoid this dismal outcome.