本篇文章主要探討Gd(acac)TPP-Cremophor Micelles為MRT造影劑的可行性。實驗中,使用罹患肝癌的大白鼠和皮下腫瘤的小白鼠二種動物模式,利用42.5MHz的光譜儀和放射性核種153Gd物分布的特性。結果顯示Gd(acac)TPP-Cremophor Micelles的靶的器官為肝臟與脾臟,它主要由肝臟與腎臟代謝;在藥物注入24小時後,正常肝臟與肝腫瘤的滯留比為2.1;而皮下瘤與肌肉的藥物滯留比值為2.5。無論從具有肝腫瘤的大白鼠或是具有皮下腫瘤小白鼠的磁振造影影像顯示,二者皆能得到腫瘤與周圍正常組織清晰的對比影像。
The Gd(acac)TPP-cremophor micelles were prepared as a potential MRI contrast agent in this research. Two experimental animal models were studied: one was using hepatoma-bearing rats and the other, subcutaneous sarcoma-bearing mice were employed. Both models were tested with a 42.5 MHz spectrometer and biodistribution study of radioisotope153Gd. The results showed that target organs of the Gd(acac)TPP-cremophor micelles studies were liver and spleen respectively, and its metabolic pathway were mainly by liver and kidney. The retention ratio of the Gd(acac)TPP-crephomor micelles in normal liver to that of in hepatoma was to be 2.1, and in subcutaneous sarcoma to that in muscle was 2.5, after twenty-four hours administration, respectively. MR studies of the two models gave a satisfactory image contrast to the tumors.