This article describes the nursing experience in caring for a 25-year-old female patient who was hospitalized with infective endocarditis due to habitual drug addiction. Upon admission, she suffered from numerous physical and psychological problems. Data were collected using intensive observation, individual interviews, and chart review between June 30(superscript th) and July 6(superscript th), 2005. The major health problems identified using Gordon's 11 Functional Health Assessment were ineffective airway clearance, risk for infection, and ineffective individual coping. During the caring process, the authors utilized multiple nursing interventions, including enhancement of support from family members, giving supportive encouragement and helping in release of negative emotion, improving individual coping skills, and increasing confidence of drug withdrawal. By sharing this caring experience, it was expected that nurses who take care of other drug-addicted patients can devote their time in understanding the psychological aspects of the patients. Instead of stigmatizing drug-addicted patients, nurses need to use empathy to provide individual care.