A 1-year- and 9-months-old, intact female, Afghan hound was presented with lameness and a gradual increasing soft-tissue mass in the right rearlimb during the last 6 weeks after femoral fracture. Fine-needle biopsy showed that the lesion was malignant tumor of bone origin. Amputation through disarticulating the coxofemoral joint was conducted. The final diagnosis of chondrosarcoma was based on histologic examination. Subsequently adjuvant chemotherapy with carboplatin and piroxicam were administered for 3 cycles. The dog remained more than 36 months of disease- free interval after surgery followed by adjuvant chemotherapy. In this case, aggressive treatment of femoral chondrosarcoma through amputation followed by adjuvant chemotherapy to prolong disease-free interval as well as survival time is beneficial.